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SynIRgy™

BIOLUMINESCENCE, NIR-II IMAGING

Combining High-Sensitivity Tumor Localization and High-Resolution Deep Tissue Tracking

A remarkable advancement in the preclinical field, the SynIRgy system combines bioluminescence, NIR-I and NIR-II imaging for the precise colocalization of tumors (bioluminescence), with the advantage of sharp, high resolution imaging (NIR-II). The NIR-II is a more consistent complementary modality to bioluminescence, able to collect ballistic photons from deeper in the tissue. The combination with NIR-I allows the use the larger list of already validated dyes in this range, before a possible transition to NIR-II. SynIRgy is the perfect combination of the power of NIR-II and the advantages of NIR-I.

Technology

Category

Bioluminescence Imaging NIR-I & NIR-II Imaging

A Growing Spectrum of Solutions

Overview
Technical Specifications
Applications
Videos

Engineered to accelerate discoveries across a diverse suite of advanced preclinical applications

Fluorescence Guided Surgery (FGS) & Resection

Achieves binary, unambiguous tumor delineation to drastically minimize the risk of missed malignant residues compared to NIR-I imaging.

Vascularization & Lymphatic Tracking

Maps microvascular structures, angiogenesis, lymph nodes, and real-time lymphatic drainage with crystal clarity.

Fluorescent Label Multiplexing

Simultaneously tracks distinct anatomical and molecular signals within the same model by isolating different emission bandwidths across the NIR-II window.

Multiplexing

Reg : Zhong et al, Multiplexed Short-wave Infrared Imaging Highlights Anatomical Structures in Mice, bioRxiv

Multiplexing Capabilities

Lymphatic and Vascular Signals in the Same Mouse and Different Emission Bandwidths in the NIR-II Region.

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Technical Specifications

Visible camera

NIR-II camera

Technical Specifications

Emission spectral range

Visible camera

400-1000 nm

NIR-II camera

900-1600 nm

Technical Specifications

Imaging modes

Visible camera

Fluorescence, reflectance, overlay

NIR-II camera

Fluorescence, reflectance, overlay

Technical Specifications

Emission filters

Visible camera

Up to 12 emission channels

NIR-II camera

Up to 6 emission channels

Technical Specifications

Illumination source

Visible camera

Lasers at 465, 520, 670,760, 808, and 890 nm

and adjustable power density

NIR-II camera

Lasers at 465, 520, 670,760, 808, and 890 nm

and adjustable power density

Technical Specifications

Lens

Visible camera

35 mm f/0,95

NIR-II camera

50 mm f/1,4

Technical Specifications

Field of view

Visible camera

132 mm x 132 mm

3 mice capacity

NIR-II camera

3 mice sequential view

Technical Specifications

Stage

Visible camera

Stage Motorized XYZ

NIR-II camera

Stage Motorized XYZ

Technical Specifications

Dimensions

(L x W x H)

Visible camera

92 x 76 x 110 cm

NIR-II camera

92 x 76 x 110 cm

Technical Specifications

Stage temperature

Visible camera

25 to 40°C

NIR-II camera

25 to 40°C

Technical Specifications

Anesthetic tubing and nosecone

Visible camera

Anesthetic nosecone supplied

NIR-II camera

Anesthetic nosecone supplied

Technical Specifications

Single image data format

Visible camera

HDF5, FITS, PNG, JPG, TIFF

NIR-II camera

HDF5, FITS, PNG, JPG, TIFF

Technical Specifications

Software

Visible camera

PC (Windows - 64-bits) with PHySpec™ control and analysis software

(Computer included)

NIR-II camera

PC (Windows - 64-bits) with PHySpec™ control and analysis software

(Computer included)

Technical Specifications

Power requirement

Visible camera

120 VCA / 6,4 A / 50-60 Hz

NIR-II camera

230 VCA / 3,3 A / 50-60 Hz

Technical Specifications

Type

Visible camera

EMCCD or qCMOS

NIR-II camera

InGaAs (Alizé™ 1.7)

Technical Specifications

FPA

(Detector Array)

 

Visible camera

512 x 512 pixels

NIR-II camera

640 x 512 pixels

Technical Specifications

Cooling

 

 

Visible camera

-80 °C

NIR-II camera

-60 °C

Technical Specifications

Quantum efficiency

 

 

Visible camera

＞90 % @ 600 nm, ＞70 % de 400 à 800 nm

NIR-II camera

＞70 % de 900 à 1600 nm

Technical Specifications

Spectral probe

(optionnal)

 

Visible camera

For real-time acquisition of spectrum on single point of the animal

NIR-II camera

For real-time acquisition of spectrum on single point of the animal

Technical Specifications

Anesthesia system

(optionnal)

 

Visible camera

Available on demand

NIR-II camera

Available on demand

Photon etc. - Specsheet - SynIRgy™

In Vivo NIR-II Imaging: Contact-Free Monitoring Heartbeat & Respiratory Rate

High-speed imaging made available by the fast frame rates of InGaAs cameras allows for contact-free cardiography and respiratory rate measurements in both anesthetized and awake animals. Such contact-free measurements of awake mice obtained without the use of any restraining device could drastically change studies procedures in labs.

IR VIVO Guided Tour

IR VIVO is an infrared multispectral imager for small animal studies. This system benefits from reduced light scattering, absorption and auto-fluorescence by using a detection system in the near and short-wave infrared. Visualize your biomarkers in vivo and in real-time with optimized contrast resolution and sensitivity. IR VIVO takes advantage of the most recent developments in SWIR imaging with an ultra-low-noise InGaAs camera (Alizé 1.7 or ZephIR 1.7), novel homogeneous illumination and powerful analytical software to provide an unprecedented combination of fast, high resolution and deep imaging.

Custom Products

Beyond our standard product lines, we bring to bear our know-how through collaborations with industry and researchers both local and international.

It’s in our DNA to build systems that measure up to the high standards set by our customers in science and industry.

Visit our Special Projects page or contact us if you can’t find what you’re looking for in our standard product lines.

Special Projects