Open near infrared fluorescence imaging for Fluorescence Guided Surgery (FGS) and Small Animal Imaging
The LightIR is an open fluorescence imaging device designed for preclinical fluorescence imaging or clinical research.
Vascular imaging in mouse after injection of NIR-II fluorescent nanoparticles
Key Features:
1. Near infrared fluorescence and NIR-II fluorescence
2. Preclinical studies, or clinical studies under IRB approval
3. Small or large animals
List of common fluorescent moieties used with the LightIR:
- Cy5, Cy5.5, Cy7, IRDye 700 and IRDye 800 from LiCOR, Indocyanine Green (ICG), ZW 800
- Rare earth (lanthanides), quantum dots and various fluorescent nanoparticles
- The various IVISense fluorescent agents (680, 700, 800)
- Alexa Fluor AF 680, AF 700, AF 750, AF 790
- infrared fluorescent protein: iRFP
Near infrared and NIR-II fluorescence
- Limited autofluorescence
- Great depth penetration
- Better resolution
NIR-II fluorescence (900 to 1650 nm)
- Virtually no autofluorescence
- Imaging through skull, bone, melanin (melanoma studies)
Product Specifications
Imaging modes | NIR-I or NIR-II fluorescence, brightfield, subtracted, overlay. Optional: RGB brightfield |
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Real-time processing | Background subtraction, brightfield/fluorescence overlay |
Emission spectral range | NIR-I : 650 - 900 nm, NIR-II : 900 - 1600 nm |
Fluorescent channels | 1 or 2 channels |
Available excitation wavelengths | 640 nm, 690 nm, 750 nm, 785 nm, 808 nm, 980 nm |
Emission filters | Set according to chosen excitation wavelengths |
Field of view | 7 cm x 7 cm |
Detector | CMOS (NIR-I) or Alize 1.7 InGaAs (NIR-II) |
Image size (px) | 1024 x 1024 (NIR-I) or 512 x 512 (NIR-II) |
Output format | TIFF images (16 bits) with metadata |
Spec Sheet
Applications
Publications
Journal of Medicinal Chemistry
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Design of Bimodal Ligands of Neurotensin Receptor 1 for Positron Emission Tomography Imaging and Fluorescence-Guided Surgery of Pancreatic Cancer
Colloids and Surfaces B: Biointerfaces
6-Aminocaproic acid as a linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green
Biomolecules
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
The Design and Preclinical Evaluation of a Single-Label Bimodal Nanobody Tracer for Image-Guided Surgery
Journal of Medicinal Chemistry
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Development of an Easily Bioconjugatable Water-Soluble Single-Photon Emission-Computed Tomography/Optical Imaging Bimodal Imaging Probe Based on the aza-BODIPY Fluorophore
Physiological reports
- Physiology
- Clinical
Gravity and lymphodynamics
Bioconjugate Chemistry
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Synthesis and Preclinical Fluorescence Imaging of Dually Functionalized Antibody Conjugates Targeting Endothelin Receptor-Positive Tumors
Journal of Medicinal Chemistry
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Development of an Immuno-SPECT/Fluorescent Bimodal Tracer Targeting Human or Murine PD-L1 on Preclinical Models
European Journal of Pharmaceutics and Biopharmaceutics
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Sustained release of a human PD-L1 single-domain antibody using peptide-based hydrogels
European Journal of Cardio-Thoracic Surgery
- Physiology
- Clinical
Octreotide improves human lymphatic fluid transport a translational trial
ACS Publications
- Biochemistry & Nanosensors
- Pharmacology
Real-Time Imaging of Hepatic Inflammation Using Hydrogen Sulfide-Activatable Second Near-Infrared Luminescent Nanoprobes
Pharmaceutics
- Biochemistry & Nanosensors
Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles
Advanced Functional Materials
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Hesperetin Nanoparticle Targeting Neutrophils for Enhanced TBI Therapy
Chemical Communications
- Biochemistry & Nanosensors
Tailoring the SWIR emission of gold nanoclusters by surface ligand rigidification and their application in 3D bioimaging
Biomaterials Science
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
Lipoprotein interactions with water-soluble NIR-II emitting aza-BODIPYs boost the fluorescence signal and favor selective tumor targeting
Advanced Science
- Biochemistry & Nanosensors
- Neuroscience
- Pharmacology
Ligustrazine Nanoparticle Hitchhiking on Neutrophils for Enhanced Therapy of Cerebral Ischemia-Reperfusion Injury
bioRxiv
- Biochemistry & Nanosensors
- Oncology
- Pharmacology
An EGF-modified PLGA-lanthanide nanoplatform for combined NIR-II cancer imaging and targeted drug delivery
American Journal of Physiology-Heart and Circulatory Physiology
- Physiology