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Infrared Imaging in Preclinical and Clinical Researches

From biochemistry to small animal imaging: we show you the light

Preclinical imaging is one of the key areas where infrared imaging is making a significant impact. Researchers developing the therapies of tomorrow need to have tools to track and monitor disease progression and therapeutic efficiency of their drug candidates or therapeutic strategies. Being able to track precisely the growth of a tumor or the progression of an infection, for example, is critical to the researcher in order to correctly select which drugs and techniques are worth developing further.

Photon etc. has a strong focus on imaging in the second infrared biological window (1- 1.7 µm), also called NIR-II (near infrared II) imaging where tissues are more translucent than in the visible range.

Fluorescence in this second biological window offers the possibility to detect deeper signals and get a sharper measurement of emitted light within tissue in living organisms, over the more conventional visible and near infrared fluorescence (400 to 900 nm). Combined with the right fluorescent dyes, it can therefore help detect smaller or deeper sources of signal – whether they are labeled tumors, infection sites or pathological or physiological processes. NIR-II photons can also cross certain types of tissues better than shorter wavelengths, like bones and skull or melanin, making fluorescence imaging accessible to new fields.

The IR Vivo preclinical imaging system, our flagship instrument in this segment, represents a significant advancement for researchers in life sciences seeking to visualize biomarkers in small animal studies with precision and accuracy. This system utilizes infrared multispectral imaging and the absence of autofluorescence to allow researchers to unlock valuable insights and achieve significant progress in their investigations.

Bioluminescence is another important, highly sensitive in vivo optical imaging modality popular for tumor growth monitoring in small animals. We now propose the most versatile optical imaging system on the market that can perform bioluminescence, visible and NIR-I fluorescence, and NIR-II fluorescence – within a single instrument, called SynIRgy. Protocols combining these different techniques, and with the benefit of a great number of filters for multispectral imaging, are now accessible to researchers with the SynIRgy system.

Our wide range of NIR products also includes the IRina and ClaIR, two state-of-the-art instruments that enable researchers to measure fluorescence emission from nanosensors or new dyes, as well as perform microplate reading applications. IRina is a stand alone in vivo spectral probe that can deliver full spectral measurements in the NIR-II range directly on the animal, while ClaIR is a microplate reader capable of capturing the full fluorescence and transmittance spectra.

Photon etc. acquired in 2022 Kaer Labs, for fluorescence guided surgery (FGS) on small or large animals or for clinical trials, and the Kratoscpe for 3D ex vivo imaging of whole organs with fluorescence or autofluorescence, making its portfolio even larger for in vitro, in vivo and ex vivo optical imaging in Life Sciences.

Photon etc. is committed to providing the highest quality imaging solutions for the life sciences sector. Our state-of-the-art imaging systems are designed to be easy to use and provide the most accurate and reliable results possible. With our expertise and experience, we can help you achieve your research goals and make a significant impact in your field.

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Photon etc. is a pioneer in the field of NIR-II optical imaging with turnkey imaging systems that allow precise characterization of activity-based sensors and targeted probes in the second biological window.

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Beyond our standard product lines, we bring to bear our know-how through collaborations with industry and researchers both local and international. It’s in our DNA to build systems that measure up to the high standards set by our customers in science and industry. Please contact us if you don’t see what you are looking for in our standard product lines.

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