NIR-II Preclinical Imager
Imaging in the Second Biological Window
IR VIVO is an infrared multispectral imager for small animal studies. This system benefits from reduced light scattering, absorption and auto-fluorescence by using a detection system in the near and short-wave infrared. Visualize your biomarkers in vivo and in real-time with optimized contrast resolution and sensitivity. IR VIVO takes advantage of the most recent developments in SWIR imaging with an ultra-low-noise InGaAs camera (Alizé 1.7 or ZephIR 1.7), novel homogeneous illumination and powerful analytical software to provide an unprecedented combination of fast, high resolution and deep imaging.
NIR-II Imaging properties
- High spatial resolution
- High temporal resolution (real-time dynamics)
- Non-ionizing & non-invasive
- Good penetration depth (10x greater than traditional visible optical systems).
Product Specifications
| Emission spectral range | 850-1620 nm extension available in the visible |
|---|---|
| Filter type | Multispectral: filter wheel. Hyperspectral: HyperCube™ (< 4nm spectral resolution (FWHM)). Single point detection: spectral probe. |
| Illumination source | 760 nm or 808 nm laser at 1 mW/mm². Other sources available upon request. |
| Field of view | Variable from 8 x 4 cm to 15.6 x 12.5 cm |
| Dimensions | Tabletop: 77 x 60 x 98 cm |
| Stage temperature | Up to 40 °C |
| Anesthetic tubing and nosecone | Three mice anesthetic gaz manifold supplied |
| Software | PC (Windows10 - 64-bits) with PHySpec™ control and analysis software (Computer included) |
| Type | InGaAs (Alizé™ 1.7 or ZephIR™ 1.7) |
|---|---|
| FPA size (px) | 640 x 512 |
| Pixel size (µm) | 15 |
| Quantum efficiency | > 70% 0.95 - 1.67 µm at 25 °C and > 70% 0.89 - 1.62 µm at -50 °C |
Spec Sheet
Applications
Publications
Journal of BioPhotonics
- Preclinical
The near-infrared autofluorescence fingerprint of the brain
Nature Communications
- Preclinical
Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging
Expert Opinion on Drug Discovery
- Pharmacology
In vivo near-infrared fluorescent optical imaging for CNS drug discovery
PloS one
- Biochemistry & Nanosensors
- Carbon-Based Materials
Long-Term in Vivo Biocompatibility of Single-Walled Carbon Nanotubes
Nano Letters
- Biochemistry & Nanosensors
- Oncology
- Carbon-Based Materials
An in Vivo Nanosensor Measures Compartmental Doxorubicin Exposure
Science Translational Medicine
- Biochemistry & Nanosensors
- Carbon-Based Materials
An Optical Nanoreporter of Endolysosomal Lipid Accumulation Reveals Enduring Effects of Diet on Hepatic Macrophages in Vivo
Science Advances
- Biochemistry & Nanosensors
- Oncology
Noninvasive Ovarian Cancer Biomarker Detection via an Optical Nanosensor Implant
Videos
In Vivo NIR-II Imaging: Contact-Free Monitoring Heartbeat & Respiratory Rate
High-speed imaging made available by the fast frame rates of InGaAs cameras allows for contact-free cardiography and respiratory rate measurements in both anesthetized and awake animals. Such contact-free measurements of awake mice obtained without the use of any restraining device could drastically change studies procedures in labs.
Real-Time Biodistribution and Pharmacokinetics of ICG in a Mouse Using NIR-II Fluorescence
Video of IR VIVO imaging experiment showing the biodistribution and pharmacokinetics of ICG in real time. IR VIVO is able to visualize NIR probes at high resolutions. From one single injection, it was possible to obtain measurements of heartbeats, respiration and intestinal contraction rates.
In Vivo NIR-II Imaging of Liver Metabolism, Hepatobiliary Elimination & Gastro-Intestinal Motility
With a simple tail-vein injection of ICG, we can study liver metabolism, measure hepatobiliary elimination and monitor gastrointestinal motility simultaneously in vivo and contact-free. Such a straightforward method to image the intestine could help research on metabolic diseases.
IR VIVO Guided Tour
IR VIVO is an infrared multispectral imager for small animal studies. This system benefits from reduced light scattering, absorption and auto-fluorescence by using a detection system in the near and short-wave infrared. Visualize your biomarkers in vivo and in real-time with optimized contrast resolution and sensitivity. IR VIVO takes advantage of the most recent developments in SWIR imaging with an ultra-low-noise InGaAs camera (Alizé 1.7 or ZephIR 1.7), novel homogeneous illumination and powerful analytical software to provide an unprecedented combination of fast, high resolution and deep imaging.
White Papers
In Vivo NIR-II Imaging: A Disruptive Force for Preclinical Research
Authors Stephen Marchant, Jacob Yvon-Leroux and Émilie Beaulieu Ouellet