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IR VIVO™

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IR VIVO™

NIR-II IN VIVO Imaging

Small animal Imaging in the Second Near-Infrared (NIR-II) Window

The IR VIVO family stands as a transformative breakthrough in the realm of small animal optical imaging.

Empower your research endeavors by gaining the ability to visualize biomarkers in their dynamic in vivo context, all in real-time. With a keen focus on optimizing contrast resolution and sensitivity, IR VIVO utilizes state-of-the-art NIR-II technology, anchored by Photon etc. ultra-low-noise InGaAs camera (Alizé 1.7 or ZephIR 1.7). Complemented by novel homogeneous illumination and robust analytical software, this system delivers an unparalleled fusion of rapid, high-resolution, and profound imaging capabilities, cementing its role as a monumental advancement in the bioluminescence imaging field of small animal optical imaging system for driving significant strides in biodistribution studies and cancer research.

Real-Time Biodistribution of ICG in a Mouse Using NIR-II Fluorescence Imaging

The IR VIVO family has three flavors:

  1. IR Vivo: Experience the pinnacle of small animal fluorescence imaging with the state-of-the-art IR Vivo model, the standard system for the NIR-II field. Elevate your research with unparalleled sensitivity, resolution, and imaging capabilities.
  2. Essence: Simplify your journey into in vivo imaging with the Essence model. Streamline your research endeavors, achieve swift and clear insights without compromising on quality.
  3. SynIRgy: Enter a new era of fluorescence imaging synergy with the SynIRgy model. Harness the combined power of near-infrared ranges and bioluminescence for a comprehensive biomarker visualization and achieve a perfect balance of resolution and sensitivity for groundbreaking biodistribution studies and cancer research advancements.

Product Specifications

IR VIVO Familly
IR VIVO Essence SynIRgy
Emission spectral range 900-1600 nm 900-1600 nm 400-1000 nm (Visible camera) 900-1600 nm (NIR-II camera)
Filtering Filter wheel with up to 6 emission channels Filter wheel with up to 6 emission channels Filter wheel with up to 6 emission channels
Illumination source Laser at 670, 760, 808 and 890 nm and adjustable power density Laser at 808 and 890 nm and adjustable power density Laser at 465, 520, 670, 760 et 808 nm and adjustable power density
Lens 50mm f/1.4 lens 50mm f/1.4 lens VIS: 35mm f/0.95 NIR-II: 50mm f/1.4
Field of view 80 x 64 mm to 50 x 40mm Variable FOV for 1 mouse or individual organ view Fixed FOV for 1 mouse imaging: 80 x 64 mm 80 x 64 mm to 50 x 40mm Variable FOV for 1 mouse or individual organ view
Stage Manual XY and motorize Z Fixed sample stage Motorized XYZ
Dimensions ( L x W x H) 77 x 60 x 98 cm 77 x 60 x 98 cm 92 x 76 x 110 cm
Camera type InGaAs (Alizé™ 1.7) InGaAs (Alizé™ 1.7) EMCCD & InGaAs (Alizé™ 1.7)

Spec Sheet

Applications

Publications

Videos

IR VIVO Guided Tour

IR VIVO is an infrared multispectral imager for small animal studies. This system benefits from reduced light scattering, absorption and auto-fluorescence by using a detection system in the near and short-wave infrared. Visualize your biomarkers in vivo and in real-time with optimized contrast resolution and sensitivity. IR VIVO takes advantage of the most recent developments in SWIR imaging with an ultra-low-noise InGaAs camera (Alizé 1.7 or ZephIR 1.7), novel homogeneous illumination and powerful analytical software to provide an unprecedented combination of fast, high resolution and deep imaging.

In Vivo NIR-II Imaging: Contact-Free Monitoring Heartbeat & Respiratory Rate

High-speed imaging made available by the fast frame rates of InGaAs cameras allows for contact-free cardiography and respiratory rate measurements in both anesthetized and awake animals. Such contact-free measurements of awake mice obtained without the use of any restraining device could drastically change studies procedures in labs.

Real-Time Biodistribution and Pharmacokinetics of ICG in a Mouse Using NIR-II Fluorescence

Video of IR VIVO imaging experiment showing the biodistribution and pharmacokinetics of ICG in real time. IR VIVO is able to visualize NIR probes at high resolutions. From one single injection, it was possible to obtain measurements of heartbeats, respiration and intestinal contraction rates.

In Vivo NIR-II Imaging of Liver Metabolism, Hepatobiliary Elimination & Gastro-Intestinal Motility

With a simple tail-vein injection of ICG, we can study liver metabolism, measure hepatobiliary elimination and monitor gastrointestinal motility simultaneously in vivo and contact-free. Such a straightforward method to image the intestine could help research on metabolic diseases.

White Papers

In Vivo NIR-II Imaging: A Disruptive Force for Preclinical Research

Authors Stephen Marchant, Jacob Yvon-Leroux and Émilie Beaulieu Ouellet

Abstract

In vivo imaging in the second near-infrared biological window (NIR-II) is in its early stages but will undoubtedly affect life science research on many levels. The NIR-II (short-wave infrared, or SWIR) imaging modality is not affected by drawbacks of light propagation in living tissues in the same way that other techniques are. Thus, it enables much deeper real-time imaging of optical probes in…

Download the white paper

Custom Products

Beyond our standard product lines, we bring to bear our know-how through collaborations with industry and researchers both local and international. It’s in our DNA to build systems that measure up to the high standards set by our customers in science and industry. Please visit our Special Projects page or contact us if you don’t see what you are looking for in our standard product lines.

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