Skip to main content

Journal of Biophotonics

  • Nanoparticles
  • Biochemistry & Nanosensors

Kinetic Analysis of Nanoparticle-Protein Interactions Using a Plasmon Waveguide Resonance

Authors Farshid Bahrami, Mathieu Maisonneuve, Michel Meunier, Arthur O. Montazeri, Yujin Kim, Nazir P. Kherani, J. Stewart Aitchison, and Mo Mojahedi


A plasmon waveguide resonance (PWR) sensor is proposed for studying the interaction between gold nanoparticles and proteins. The ability of the PWR sensor to operate in both TM and TE Polarizations, i.e. its polarization diversity, facilitates the simultaneous spectroscopy of the nanoparticles surface reactions using both polarizations. The response of each polarization to streptavidin-biotin binding at the surface of gold nanoparticles is investigated in real time. Finally, using the principles of multimode spectroscopy, the nanoparticle’s surface reactions are decoupled from the bulk solution refractive index variations.